P 416 Lipofuscin accumulation in the retinal pigment epithelium and fatty acid diet
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چکیده
منابع مشابه
P 416 Lipofuscin accumulation in the retinal pigment epithelium and fatty acid diet
B Confirming the diagnosis of night blindness in our patient, the scotopic response in his electroretinogram (ERG) was distinctly reduced while the photopic response was normal. When his blood was examined for a low level of vitamin A as a possible cause for night blindness, we found the value to be reduced below normal (17 pg/dl versus 25-70 pg/dl in normal subjects). Treatment with vitamin A ...
متن کاملIron-induced accumulation of lipofuscin-like fluorescent pigment in the retinal pigment epithelium.
PURPOSE One of the most prominent changes that occurs in the retinal pigment epithelium during senescence is the progressive accumulation of the autofluorescent pigment lipofuscin. Experiments were conducted to evaluate the role of nonenzymatic oxidation of photoreceptor outer segments in retinal pigment epithelium lipofuscin formation. METHODS Albino Fischer rats were given intravitreal inje...
متن کاملRetinal Pigment Epithelium Lipofuscin Proteomics*□S
Lipofuscin accumulates with age in the retinal pigment epithelium (RPE) in discrete granular organelles and may contribute to age-related macular degeneration. Because previous studies suggest that lipofuscin contains protein that may impact pathogenic mechanisms, we pursued proteomics analysis of lipofuscin. The composition of RPE lipofuscin and its mechanisms of pathogenesis are poorly unders...
متن کاملZinc Deficiency Leads to Lipofuscin Accumulation in the Retinal Pigment Epithelium of Pigmented Rats
BACKGROUND Age-related macular degeneration (AMD) is associated with lipofuscin accumulation whereas the content of melanosomes decreases. Melanosomes are the main storage of zinc in the pigmented tissues. Since the elderly population, as the most affected group for AMD, is prone to zinc deficit, we investigated the chemical and ultrastructural effects of zinc deficiency in pigmented rat eyes a...
متن کاملThe 5HT1a Receptor Agonist 8-Oh DPAT Induces Protection from Lipofuscin Accumulation and Oxidative Stress in the Retinal Pigment Epithelium
Age-related macular degeneration (AMD), a major cause of blindness in the elderly, is associated with oxidative stress, lipofuscin accumulation and retinal degeneration. The aim of this study was to determine if a 5-HT(1A) receptor agonist can reduce lipofuscin accumulation, reduce oxidative damage and prevent retinal cell loss both in vitro and in vivo. Autophagy-derived and photoreceptor oute...
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ژورنال
عنوان ژورنال: Vision Research
سال: 1995
ISSN: 0042-6989
DOI: 10.1016/0042-6989(95)90676-2